In other words, now the repressor doesn't fit in the operator anymore.

换言，阻遏蛋白无法再与操纵结合。

In other words it lacks these little prongs we'll say that fit in the operator.

换句话说，它缺少那些能够嵌入操纵的“小突起”。

Well a negative control we learned about from the trp operon.

好的，我们从氨酸操纵中了解到负调控的概念。

And the other thing they'll have in an operon is called an operator.

操纵中，另一个重要的组成部分叫做操纵基因。

An operator sits right between the promoter and the genes.

操纵启动和基因间。

Positive control example I'll give you is the lac operon.

我给你举的一个正调控的例是乳糖操纵。

So the tryptophan fits again and it's going to turn off.

因此，氨酸再次充足，它将再次关闭（氨酸操纵的表达）。

And so this would be, when the repressor is here the operator is now in the off position.

因此，当阻遏蛋白此处时，操纵处关闭状态。

And the negative control is the trp operon.

负调控的例是氨酸操纵。

And so let's talk about how this works is the lac operon in bacteria because this the first one we really started to understand.

那么，让我们来谈谈这个机制是如何细菌的乳糖操纵中运作的，因为这是我们最先开始理解的一个例。

A repressor will plug right into the operator, so it's going to fit right here, and as long as the repressor is available, RNA polymerase can't get on.

阻遏蛋白会正好嵌入操纵中，因此它将恰好适应这里， 只要阻遏蛋白存，RNA聚合酶就无法进入。