And children with progeria are born with a T at a single position in their genome where you have a C, with the devastating consequence that these wonderful, bright kids age very rapidly and pass away by about age 14.

而患有症孩子出生时，他们基因组中有一个T位于你有C位置，伴随着毁灭性后果，这些优秀、聪明孩子会非常迅速地老并在14岁左右过世。

Most women have a normal puberty with regular periods before the disorder develops, but then start having troubles when premature ovarian failure occurs.

大多数女性在疾病进展之前都拥有正常青春期与规律月经周期；但当卵巢发生时，就开始出现问题。

" Isn't it hard living with Progeria" ? or

" 伴随着症生活是不是很艰难？"

I just want to give you some more information about Progeria.

我想让大入了解一下症情况。

They had a condition called progeria, meaning that they aged much more rapidly than normal mice.

这些小白鼠都处在一种叫做状态。意思是，这些小白鼠比一般正常状态下小白鼠要老快很多。

There are two proposed mechanisms that could explain how premature ovarian failure develops.

有两种机制可以解释卵巢发生。

Some symptoms of premature ovarian failure are directly related to the absence of ovulation and the low levels of estrogen and progesterone.

卵巢一些症状与无排卵、雌激素孕激素水平低下直接相关。

" What daily challenges of Progeria do you face" ?

又或 " 患有症你每日都会面临什么样挑战" ？

What I love about being in a group like the band, is that the music that we make together, is true, is genuine, and it supersedes Progeria.

我热衷于在一个 像乐队一样集体里，因为我们在一起制作音乐，这种音乐是真 是真诚 它完全取代了我症。

In premature ovarian failure when estrogen levels are low the pituitary gland attempts to restore balance by increasing production of gonadotropins LH and FSH.

在卵巢中，当雌激素水平较低时，垂体试图通过增加促性腺激素LH和FSH产生来恢复平衡。

And I'd like to say that, even though I have Progeria, most of my time is spent thinking about things that have nothing to do with Progeria at all.

我想说 即使我有症，我大部分时间都花在考虑一些跟症无关事情上。

Diagnosis of premature ovarian failure can be done by detecting low levels of ovarian hormones, mainly estrogen, and increased levels of LH and FSH.

卵巢诊断可通过检测出低水平卵巢激素，主要是雌激素以及升高LH和FSH水平来判定。

Now, in premature ovarian failure, the follicles stop responding to gonadotropin stimulation earlier than usual - that being before the age of 40.

而在卵巢患者中，卵泡停止对促性腺激素刺激反应，即在40岁之前。

Eggs are taken from a donor, fertilized, and then implanted into the hormonally prepared uterus of the woman with premature ovarian failure.

从捐赠者体内取出卵子，受精，然后植入卵巢妇女经激素准备子宫内。

All right, as a quick recap, premature ovarian failure occurs before age 40 and is caused by not having enough follicles in the ovaries or having follicles that don't respond to gonadotropins.

好！快速回顾一下：卵巢发生在40岁之前，是由于卵巢中没有足够卵泡或卵泡对促性腺激素无反应。

I got some on the way my muscles, my muscles drop early, early spring.

- 我肌肉在路上得到了一些，我肌肉在春。

Miss Bartlett assumed her favourite role, that of the prematurely aged martyr.

巴特利特小姐扮演了她最喜欢角色，即烈士。

From this day on Maslova began to lead a life to which hundreds of thousands of women are driven, and which, in nine cases out of ten, ends in painful disease, premature decrepitude and death.

从这一天起，玛斯洛娃开始过上了成千上万妇女被迫过生活，而这种生活在十分之九情况下都以痛苦疾病、和死亡告终。

Now we know menopause can happen really at almost any age through premature ovarian failure or insufficiency or early menopause.

现在我们了解到，年期几乎可以在任何年龄发生，无论是由于卵巢、功能不全还是期年期。

Wait a minute… no, actually I am in my late 40s, so maybe I'm not premature aging.

等一下… … 不， 实际上我快50岁了，所以可能我不是。