Defeat's worry, feels inferior, dispiritedly, is pessimistic, fears, medicinal preparation toxicant, is poisoning their soul likely, caused them to contract English dwarfism generally.
Historical precedent suggests that science and politics can overcome resistance from businesses that pollute and poison but it takes time, and success often starts small.
The idea that " bad" novels could poison someone's thinking, could plant roots in the recesses of her brain only to send out shoots of florid prose years later, was an alarming one.
A few weeks before, Vincent, in a manic episode, had tried to poison himself, by swallowing paint and turpentine, literally killing himself with colour, and now he was using the same tubes to produce this.