As the estrogen is combined with osteoclast, it can inhibit the activity of lysomal enzyme, inhibit bone resorption and decrease the ability of osteclast on forming cavate in bone slice.
Once it reaches the lungs, it gets ingested by alveolar macrophages and inside macrophages, it gets wrapped up in a vesicle called phagosome, which normally merges with lysosomes to kill invading bacteria.
All right, as a quick recap, Tay-Sachs disease is a lysosomal storage disease that results in a buildup of GM2 ganglioside in neurons of the central nervous system.
With most cases, the macrophage then fuses the phagosome with a lysosome which has hydrolytic enzymes that can pretty much break down any biochemical molecules.
You've got your radiator, ratty, throttle, body rats, mission differ, rats, strats, top rat, thermos rat traction and control, and your lytic converter.