So why would you like are all non albicans candida?

那么，为什么你会想知道所有非白色念珠菌的念珠菌呢？

The use of allergenic extracts of candida albicans for immunotherapy or provocation neutralization.

使用白色念珠菌过敏原提取物进行免疫疗法或激发-中和。

And so are all candida albicans individual, you know, cells or whatever, capable of this transformation?

此， 所有白色念珠菌个体，即那些细胞或诸如此类的物， 是否都具备这转变能力呢？

Because Albicans is a commensal, but these don't seem to be commensals.

为白色念珠菌是一共菌，但这些似乎不是共菌。

We see resistance in C. auris, some strains, to almost all of the antifungals that we use.

我们发现，在某些菌株中，白色念珠菌对几乎所有我们使用的抗真菌药物都耐药性。

But for most of this episode, especially for the pathogenicity part of things, I'm gonna focus on Candida albicans.

但在本节的大部分内容中， 特别是关于致病性的部分，我将重点关注白色念珠菌。

Yeah, I have the exact same timeline about 10 years ago, I like maybe one resistant Candida albicans infection a year, like maybe two.

是的，我大约十年前有过同样的经历，我可能每年会有一两次抗真菌耐药性的白色念珠菌感染。

And when the balance within the vagina is disrupted— like the pH increases or there are fewer microbes to compete with— Candida albicans may assume their disease-causing forms.

当阴道内的平衡被破坏时— — 比如 pH 值升高或与之竞争的微物减少— —白色念珠菌可能会呈现出它们的致病形式。

And I think that's also part of why they're saying call everything non-Albicans because it's like they've been renaming some things, which is important, but also gets confusing.

我认为这也是为什么他们建议将所有非白色念珠菌的菌统称为非白色念珠菌的原之一， 为这就像他们在重新命名一些事物，虽然这很重要， 但也容易造成混淆。

So the kind of most notable ones, and there are more than these two, but kind of the most notable ones are Candida auris, and we'll talk more about that later.

此， 最引人注目的几， 虽然不止这两，但尤其值得一提的是白色念珠菌，我们稍后会详细讨论它。

Probably the first case was maybe a decade ago, but now what we're seeing almost every week or so in our program is women with Candida albicans infections that are very resistant to antifungals.

可能第一例是在十年前左右，但现在我们在项目中几乎每周都能看到患有对抗真菌药物非常耐药的白色念珠菌感染的女性。