Also, between the circular and the longitudinal muscle layer, there's a plexus, or networks of nerves, which help coordinate muscle contraction and relaxation.
In the thoracic region of the spine, neural crest cells differentiate into the neurons of the sympathetic chain, lying on either side of the entire spinal cord.
That's the stage when individuals usually experience pain, although pain can also occur when the caries lesion involves the dentin layer since sensory nerve fibers travel through tubules in the dentin.