Symptoms of tuberous sclerosis are often related to the hamartomas in the brain which cause problems like seizures, learning difficulties, and cognitive deficits.
Sub-solid nodules will require longer follow-up than solid nodules as they may represent premalignant adenocarcinoma in situ or minimally invasive adenocarcinoma.
The British Thoracic Society guidelines for pulmonary nodules recommend the Herder risk model for predicting malignancy in solid pulmonary nodules after PET-CT.
And there's one more problem: each individual nodule creates a temporal instability that raises the chances the portal might collapse as you go through it.