Base editors use the programmable searching mechanism of CRISPR scissors, but instead of cutting the DNA, they directly convert one base to another base without disrupting the rest of the gene.

碱基编辑器使用CRISPR剪刀的可编搜索机制，但它们不切割DNA，而是直接将一个碱基转换为另一个碱基，而不会破坏其余的基。

We recommend reading backwards, reading out loud, and using an outside editor.

我们推荐倒读、大声朗读和使用外部编辑器。

This includes support for Epic's immersive VR Mode Editor that you saw this morning, allowing you to step inside the VR environments as you're creating them.

这包括对 Epic 的沉浸式 VR 模式编辑器的支持，大家午见到过了，你可以身临其境地创造 VR 环境。

The growing number of courses on programming are particularly good, and those can help you get familiar with languages like Python and start building programs on day one with their built-in drag-and-drop editor.

他们不断增加的编课特别出色，这些课可以帮助你熟悉像 Python 这样的语言，并通过内置的拖放编辑器在第一天就开始构建序。

But we can tell it to chop up plant DNA instead — or the DNA of other organisms — which allows us to use CRISPR as a super-precise gene editor.

但是我们可以告诉它切割植物 DNA，或者其他生物的 DNA，这使得我们可以使用 CRISPR 为超精确的基编辑器。

In fact, we engineered the first base editor, shown here, from three separate proteins that don't even come from the same organism.

，我们设计了第一个碱基编辑器，如图所示，它由三种甚至不来自同一生物体的独立蛋白质组成。

And the new courses on programming are also particularly good, which will help you get familiar with Python and start building programs on day one with their built-in drag-and-drop editor.

他们的新编课也特别优秀，可以帮助你熟悉 Python，并且在第一天就能使用内置的拖放式编辑器开始编序。

We realized that we could borrow, once again, the targeting mechanism of CRISPR scissors to bring the new base editor to the right site in a genome.

我们意识到我们可以再次借用，CRISPR剪刀的靶向机制，把新的碱基编辑器带到基组的正确位置。

And here you can use the familiar SceneKit editor to rotate the camera, navigate, and inspect objects.

你可以用熟悉的SceneKit 编辑器去反转相机、导航并检查对象。

And on the left-hand side, now I have access to a GPU report that now brings up in the standard editor a summary of all the performance counters on the timeline for all of the draw calls.

在左手边，我可以访问一份 GPU 报告，它在标准编辑器里总结出了所有的在全部绘制调用的时间线的性能计数器。

They'll help you get familiar with a language like Python so you can start building programs on day one with their built-in drag and drop editor.

它们将帮助你熟悉像 Python 这样的编语言，这样你可以在第一天就开始使用他们内置的拖放编辑器构建序。

Co-opting nature's viruses to deliver base editors instead of the molecules that give you a cold is one of several promising delivery strategies that's been successfully used.

选择大自然的病毒来传递碱基编辑器而不是让你感冒的分子是成功使用的几种有前途的传递策略之一。

And we took the notion of semantic presentation and didn't stop at source code because we now have an integrated Markdown editor as well.

我们还采用了语义表达的概念，并没有停止在源代码阶段，为现在我们有统一的 Markdown 编辑器了。

And those can help you get familiar with languages like Python and start building programs from day one with their built-in drag-and-drop editor.

这些课能帮助你熟悉 Python 等编语言，并从第一天起就使用其内置的拖放式编辑器开始构建序。

The results of our efforts are molecular machines called " base editors" .

我们的研究成果是被称为" 碱基编辑器" 的分子机器。

All right, so now on the left-hand—actually, let me change my system editor here.

好了，现在在左边，让我更改一下系统编辑器。

And you can start building programs on day one with their built-in drag-and-drop editor.

你可以在第一天就使用他们内置的拖放编辑器开始构建序。

While many of these diseases are thought to be treatable by correcting the underlying mutation in even a modest fraction of cells in an organ, delivering molecular machines like base editors into cells in a human being can be challenging.

尽管许多这些疾病被认为是可以通过纠正器官中哪怕是一小部分细胞的潜在突变来治疗的，但是在人类的细胞中，将诸如碱基编辑器之类的分子机器传送到细胞中是一个挑战。

Now, base editors don't exist in nature.

现在，碱基编辑器在本质并不存在。

Our editor now has more semantic awareness, and we've brought over the tokenized editing experience from Swift Playgrounds.

我们的编辑器现在有了更多的语义意识，我们还使用了从 Swift Playgrounds 那里带来的标记化编辑体验。