And the ALS ice bucket challenge has now reached presidential levels.

萎缩侧索硬化症的冰桶挑战活动已经到达了总统级别。

She helped care for a brother who had amyotrophic lateral sclerosis (ALS) in his 50s.

她帮助照顾了一位50岁患上萎缩性侧索硬化症的兄弟。

Over time, SMA can make it impossible for the child to move, swallow or breathe.

随着时间的推移，脊髓性萎缩症会使儿童无法移动、吞咽或呼吸。

The treatment is for spinal muscular atrophy, a rare inherited disease that affects infants.

该治疗方法适用于脊髓性萎缩症，这是一种影响婴儿的罕见遗传性疾病。

When he was 23, he was diagnosed with ALS, a real disease of the nerves.

当他23岁时，他被诊断出患有萎缩侧索硬化症，一种真正的神经疾病。

It's about as rare as ALS; there are around 7,000 new cases each year in the United States.

它和萎缩侧索硬化症一样罕见；美国每大约有7000例新病例。

Without the support of dystrophin in place, the sarcolemma essentially wilts and becomes unstable.

没有抗萎缩蛋白的支撑，膜塌缩变得不稳定。

The one other medicine for SMA approved in the U.S. is a drug called Spinraza.

美国批准的另一种治疗脊髓性萎缩症的药物叫做斯宾拉沙（Spinraza）。

She passed away over a decade ago from ALS, six months before I ever released my first YouTube video.

前，我发布第一支油管视频的 6 个月前，她因为萎缩侧索硬化去世了。

The Food and Drug Administration approved a gene therapy developed by Novartis for treating spinal muscular atrophy in children.

美国食品和药物管理局批准了诺华(Novartis)开发的一种基因疗法，用于治疗儿童脊髓性萎缩症（SMA）。

And his company's A.L.S. Wonder drug is killing people.

他公司治疗萎缩性侧索硬化的灵药吃死人了。

But in some rare cases, like Hawking’s, ALS starts earlier in life.

但一些罕见的情况下，比如霍金，萎缩侧索硬化生命早期就开始了。

Hawking’s case was also a medical marvel because of how long he lived with ALS.

霍金的病例也是医学上的奇迹，因为他患有萎缩侧索硬化的时间如此之长。

Okay, so as a quick recap: the protein dystrophin is super important for stabilizing the muscle cell membrane.

抗萎缩蛋白对纤维稳定性的维持极其重要。

He was the best-known theoretical physicist of his time despite being afflicted with ALS which left him debilitated for decades.

尽管几来受萎缩侧索硬化（ALS）的折磨，身体分虚弱，他仍曾是当下最著名的理论物理学家。

Even today, you get A.L.S., within three to five years, you die.

就算今时今日 患上萎缩侧索硬化症，不出三五也必死无疑。

It's not fair you got A.L.S. in the first place.

本身患上萎缩性侧索硬化症就很不公平。

ALS fits. It even predicts the pneumonia.

应该是A.L.S.(萎缩性脊髓侧索硬化) 这种病会引发肺炎.瘫痪恶化.

How long have you known Quentin had A.L.S.?

你知道奎汀有萎缩侧索硬化症久了？

Doug was diagnosed with ALS about 12 years ago and has since lost the ability to speak.

Doug 大约 12 前被诊断出患有萎缩侧索硬化，此后就失去了说话的能力。