A blocked duct is bad news because pancreatic juices start backing up, increasing the pressure, and leading to distention of the duct itself.

胰管阻塞件很糟糕的事，因为胰液会开始回流，增加管腔内压力，导致导管扩。

To digest a meal, these zymogens are released into the pancreatic duct, and delivered to the small intestine where they are activated by the protease trypsin.

当消化食物时，些酶原被释放入胰管，然后进入小肠，在那里它们被胰蛋白酶激活。

For example the duct may take on a chain-of-lakes pattern due to alternating stenosis and dilation of the ducts.

例如胰管造影可能会显示狭窄和扩出现的“湖链”。

With alcohol abuse it goes like this: alcohol increases zymogen secretion from acinar cells while decreasing fluid and bicarbonate production from the ductal epithelial cells.

酒精滥样引发急性胰腺炎的：酒精增加腺泡细胞分泌酶原，同时让胰管上皮细胞减少生成水和碳酸氢盐。

That gene encodes for an ion transporter, and mutations in that transporter cause the pancreatic secretions to become thick and sticky, leading to obstruction of the ducts.

个基因编码一种离子转运体，该转运体的突变会导致胰腺分泌物变得黏稠，引起胰管堵塞。

When the pancreatic acinar cells are damaged or the the pancreatic ducts are blocked, often because of alcohol abuse or gallstones, the inactive zymogens that the pancreas produces can be prematurely converted to active digestive enzymes.

通常由酒精滥或胆结石导致的胰腺腺泡细胞受损或胰管阻塞时，胰腺产生的无活性酶原可被过早转化为活性消化酶。

While the pancreatic cells that produced digestive secretions degenerated in the dogs whose pancreatic duct had been tied, the islets of Langerhans remained undamaged.

尽管结扎了胰管的狗的产生消化分泌物的胰腺细胞退化了，朗格汉斯岛却未受损伤。

The dogs whose pancreas had been removed altogether developed diabetes, as expected, while the dogs whose ducts had been tied did not.

被完全摘除胰腺的狗如预期那样发展成了糖尿病，而那些胰管被结扎的狗则没有。

They found that it wasn't necessary to ligate a dog's pancreatic ducts in order to collect insulin.

他们发现没有必要结扎狗的胰管来收集胰岛素。

It read, " Ligate pancreatic ducts of dogs." Banting's idea was to close off the small passages in a dog's pancreas that release its products into the rest of its body.

上面写着：“结扎狗的胰管。”班廷的想法关闭狗胰腺中的小通道，些通道将其产物释放到身体的其他部位。