In more severe cases, disease modifying anti-rheumatic drugs, or DMARDs, like sulfasalazine and methotrexate can be helpful.

严重病患中，改善病情抗风湿药（DMARDs），如柳氮磺吡啶和甲氨蝶呤，是有效。

Though the precise connection between tetrahydrobiopterin and pain is still unclear, Dr Cronin and colleagues are nonetheless looking for ways to reduce its levels in the body.

尽管四氢生物蝶呤与疼痛之间确切联系仍不清楚，但 Cronin 博士及其同事仍降低其体内水平法。

After testing the impact of these drugs on mouse neurons, they identified one candidate—fluphenazine, previously prescribed for schizophrenia—that successfully inhibited not only tetrahydrobiopterin but pain too.

测试了这些药物对小鼠神经元影响后，他们确定了一种候选药物——氟奋乃静，以前曾为精神分裂症开过——不仅成功地抑制了四氢生物蝶呤，而且还成功地抑制了疼痛。

Shane Cronin, a biologist at Harvard Medical School, is part of a team of researchers that has spent more than a decade identifying a correlation between chronic pain and levels of a naturally occurring molecule in the body known as tetrahydrobiopterin.

哈佛医学院生物学家 Shane Cronin 是一个研究小组成员，该小组花了十多年时间确定慢性疼痛与体内天然存四氢生物蝶呤分子水平之间相关性。

A rheumatologist may advise you specialized treatment with: - Hydroxychloroquine - Non-steroidal anti-inflammatory drugs or NSAIDs - Steroid tablets, creams, or injections - Conventional disease-modifying anti-rheumatic drugs (DMARDs) - Drugs to control high blood pressure and high cholesterol - Immunosuppressants such as methotrexate, azathioprine, mycophenolate, cyclophosphamide.

风湿病专家可能会建议您采用以下药物进行专门治疗： - 羟氯喹 - 非甾体类抗炎药或 NSAID - 类固醇片剂、乳膏或注射剂 - 传统缓解病情抗风湿药 (DMARD) - 控制高血压和高血压药物胆固醇 - 免疫抑制剂，如甲氨蝶呤、硫唑嘌呤、霉酚酸酯、环磷酰胺。