3.The urine xanthopterin levels were determined in 29 healthy men(normal group),11 patients and 34 patients with cancer by fluorescence combined with paper chromatography.
4.Neopterin is a marker for the activation of the cell-mediated immune system,the elevation of its serum concentration is an independent predictor of cardiovascular adverse events.
3.Though the precise connection between tetrahydrobiopterin and pain is still unclear, Dr Cronin and colleagues are nonetheless looking for ways to reduce its levels in the body.
4.After testing the impact of these drugs on mouse neurons, they identified one candidate—fluphenazine, previously prescribed for schizophrenia—that successfully inhibited not only tetrahydrobiopterin but pain too.
5.Shane Cronin, a biologist at Harvard Medical School, is part of a team of researchers that has spent more than a decade identifying a correlation between chronic pain and levels of a naturally occurring molecule in the body known as tetrahydrobiopterin.
6.A rheumatologist may advise you specialized treatment with: - Hydroxychloroquine - Non-steroidal anti-inflammatory drugs or NSAIDs - Steroid tablets, creams, or injections - Conventional disease-modifying anti-rheumatic drugs (DMARDs) - Drugs to control high blood pressure and high cholesterol - Immunosuppressants such as methotrexate, azathioprine, mycophenolate, cyclophosphamide.