The permeability of blood-brain barrier (BBB) was detected by Evans Blue (EB) leakage method, and the ultrastruncture of BBB, which contained astroglia, was observed under electron microscopy.
Among other things, they provide electrical insulation, clear up excess neurotransmitters, respond to brain injuries, and form the blood-brain barrier.
Since ammonia is able to diffuse across the blood-brain barrier, it begins to interfere with brain function, causing the characteristic encephalopathy seen as Reye's disease progresses.
Opening the blood-brain barrier allows us to access more of the brain tissue and be able to increase the effectiveness or bioavailability of the therapeutics.