One type of medication is an acetylcholinesterase inhibitor, like neostigmine or pyridostigmine.

其中一种药物是乙酰胆碱酯酶（AChE）抑制剂，如新斯的明或吡斯的明。

Sarin kills by bonding with Acetylcholineserase, completely changing it's physical structure.

林通过与乙酰胆碱酯酶结，彻底改变其物理结构来致人死亡。

So, let's talk about these for a minute starting with cholinesterase inhibitors.

所以，让我们先从胆碱酯酶抑制剂开始谈一分钟。

Or just changes in acetylcholine esterase activity.

或仅是乙酰胆碱酯酶活性的变化。

And indeed, there's a fair amount of evidence showing that microplastics and nanoplastics are correlated with reductions

确实，有相当多的证据表明微塑和纳米塑与乙酰胆碱酯酶活性的降低有关。

1993 Tacrine is the first cholinesterase inhibitor drug for Alzheimer's, but is withdrawn from general use in 2013 due to safety concerns.

1993年， Tacrine是第一种用于阿尔茨海默病的胆碱酯酶抑制剂药物，但由于安全问题， 它在2013年被停止通用。

The team of doctors who have examined Navalny since his arrival on Saturday had found the presence of " cholinesterase inhibitors" in his system, the statement said.

这份声明指出，自纳瓦尔尼周六抵德以来，医生团队对他进行了检查，发现他体内存在" 胆碱酯酶抑制剂" 。

Now, since Alzheimer's has been linked to a deficiency of acetylcholine in the brain, cholinesterase inhibitors were introduced to alleviate the symptoms of the disease.

现在，由于老年痴呆症与大脑中乙酰胆碱缺乏有关，胆碱酯酶抑制剂被用来减轻这种疾病的症状。

It's important to note here that out of the three, Rivastigmine is the only one that shows significant inhibition of both acetylcholinesterase and butyrylcholinesterase.

值得注意的是，在这三种药物中，利瓦斯蒂明是唯一对乙酰胆碱酯酶和丁酰胆碱酯酶均有明显的抑制作用。

As their name suggests, cholinesterase inhibitors work simply by inhibiting cholinesterase enzymes from breaking down acetylcholine, thereby increasing both the level and duration of action of acetylcholine.

顾名思义，胆碱酯酶抑制剂只是通过抑制胆碱酯酶酶而起作用从分解乙酰胆碱，从而增加水平和持续时间乙酰胆碱的作用。

When your brain tells the muscles to stop contracting, the acetylcholine has to be removed, this is done with Acetylcholinesterase an enzyme that breaks down the acetylcholine into its constituent parts allowing your muscles to relax.

当你的大脑告诉肌肉停止收缩时，乙酰胆碱就必须被移除， 这是由乙酰胆碱酯酶这种酶来完成的， 它会将乙酰胆碱分解成其组成部分， 从而使你的肌肉得以放松。

And sure, there's a lot of animal literature showing, for instance, that there's a disruption in certain enzymatic pathways within neurons, in particular, and this is the one that intrigues me the most, a disruption in what's called acetylcholine esterase.

当然，有很多动物研究表明，例如，在神经元内的某些酶促途径中存在干扰，特别是对所谓的乙酰胆碱酯酶的干扰，这一点最让我感兴趣。