I just posted this article about how to deal with PDE5 inhibitors, non-responsiveness.

我刚发了一篇文章，讲何应对磷酸二酯酶5抑制剂无反应问题。

Integrase inhibitors stop HIV from inserting its DNA into the chromosome of a CD4 plus cell.

整合酶抑制剂阻止HIV将其DNA插入CD4阳性细胞染色体中。

PDF5 inhibitors would inhibit the breakdown, but there's nothing to inhibit the breakdown of.

磷酸二酯酶5抑制剂会抑制其分解，但并没有什么可以抑制其分解质。

Since 2009, a favorite of the US and UK has been a class of drugs known as neurominidase inhibitors, or NAIs.

自2009年以来，美国和英国一直偏爱一类被称为神经氨酸酶抑制剂（NAIs）药。

The decision about systemic disease treatment, meaning estrogen blockers, like some of you may have heard tamoxifen, aromatase inhibitors, they block estrogen.

关于系统性疾病治疗，也就雌激素阻断剂，比们中一些人可能听说过他莫昔芬，芳香化酶抑制剂，它们能阻断雌激素。

So, I wouldn't recommend someone to go and use an AI in conjunction with that, obviously, unless they've done blood work and see that.

因此，除非他们已经进行了血液检测并确认了这一点，否则我不会建议某人去使用AI（芳香化酶抑制剂）来配合治疗。

This is probably one of the number one reasons when you look at the different conditions, health conditions, comorbidities, when people don't respond to PDF5 inhibitors.

这可能看不同健康状况和共病时，人们不响应磷酸二酯酶5抑制剂首要原因之一。

After reviewing 46 studies performed on 24,000 people who have taken Tamiflu or Ralenza, a medical nonprofit known as the Cochrane Collaboration found that NAIs don't reduce the risk that you'll catch the flu.

经过审了针对24,000名服用过达菲或乐感清人进行46项研究后， 一个名为科克伦协作网医学非营利组织发现， 神经氨酸酶抑制剂并不能降低感染流感风险。

Since the study came out, officials have defended their decisions by saying that NAIs were better than nothing at all, which may in fact be true, but transparent science would have been a lot better.

自从研究公布以来，官员们一直在为自己辩护， 称神经氨酸酶抑制剂总比什么都没有好， 这或许真， 但透明科学研究会更好。

It's because most of the drugs out there, whether they're ACE inhibitors, what's called angiotensin receptor blockers, calcium channel antagonists, the main classes of drugs that treat high blood pressure aren't targeted toward restoration of nitric oxide.

这因为目前大多数药，无论血管紧张素转换酶抑制剂、所谓血管紧张素受体阻滞剂，还钙通道拮抗剂， 这些治疗高血压主要药类别， 其目标并非恢复氮氧化水平。