Another example is a tumor that produces excess aldosterone, which just like renin, leads to fluid retention.

另一个例子是肿瘤生长也会产生过多醛固，一种类似于肾素物质，会导致液体。

All that being said, in situations where somebody produces too much aldosterone, like primary hyperaldosteronism, then there's more potassium secretion by the principal cells and excreted, and therefore less potassium is retained, leading to hypokalemia.

说了这么多，在某人产生了太多醛固情况下，比如原发性醛固增多症，更多钾被主细胞分泌并排泄，这意味着更少钾被保留，导致了低钾血症。

This stimulates the release of aldosterone, which tries to bring blood pressure back up by telling the kidneys to retain more sodium and water.

这会刺激醛固释放，醛固让肾脏保留更多钠和水来量维持血压。

Treatment of hyperaldosteronism is usually with potassium-sparing diuretics, especially spironolactone, which competitively binds to aldosterone receptors on the principal and alpha-intercalated cells.

醛固增多症治疗通常使用保钾利尿剂，尤其是螺内酯：其可竞争性结合主细胞及α-闰细胞上醛固受体。

On the flip side of aldosterone, there is a group of hormones called natriuretic hormones, i. e. sodium urinating hormones.

在醛固另一面，有一组激素叫利钠激素，也就是钠尿荷尔蒙。

Aldosterone is important because its job is to hold on to sodium by conserving it not only in the kidney, but also in the salivary glands, sweat glands, and colon.

醛固要，因为它不仅能在肾脏中，还能在唾液腺、汗腺及结肠中固钠。

As the pumps collectively move more sodium into the blood under the influence of aldosterone, more potassium gets pumped into the cell, which raises the intracellular potassium concentration.

在醛固作用下，离子泵使得更多钠离子进入血中，更多钾离子进入细胞中，提升细胞内钾离子浓度。

Hyperaldosteronism can also be due to secondary causes where the pathology lies outside of the adrenal gland.

醛固增多症也可以是继发性，即病变位于肾上腺以外。

Along the same lines, drugs that reduce the effect of aldosterone can also cause hyperkalemia, and these are drugs like renin inhibitors, ACE inhibitors, angiotensin II receptor antagonists, selective aldosterone blockers, and potassium-sparing diuretics.

同理，可以降低醛固效能药物也可以导致高钾血症，例如肾素抑制剂、ACE抑制剂、血管紧张素II受体拮抗剂、选择性醛固受体阻滞剂以及保钾利尿剂等。

In primary hyperaldosteronism, the main problem is that zona glomerulosa cells secrete high levels of aldosterone, and that aldosterone has a negative feedback effect on renin, and so it actually inhibits renin production.

在原发性醛固增多症中，主要问题是球状带细胞分泌高水平醛固；醛固对肾素有负反馈作用，因而实际上抑制肾素生成。

Another study shows that when salt intake drops below 1.5 teaspoons per day, a significant increase in renin and aldosterone occurs.

另一项研究显示，当盐摄入量降至每天 1.5 茶匙以下，人体中醛固及肾素水平将大幅上升。

An important hormone that helps regulate potassium reabsorption or secretion in the kidneys is aldosterone.

肾脏中一种帮助调节钾吸收或分泌要激素叫醛固。

The most common primary cause is called idiopathic hyperaldosteronism, because the zona glomerulosa has an increase in the number of cells secreting aldosterone, but it's not really clear why this happens.

最常见原发性病因称为特发性醛固增多症：这是由于球状带分泌醛固细胞数量增加，但目前尚不清楚为什么会发生这种情况。

These drugs inhibit Angiotensin Converting Enzyme, hindering an important step in the RAA system resulting in lower aldosterone and lower blood pressure.

这种药物通过抑制血管紧张素转化酶作用（RAA 系统关键作用之一），以达到降低醛固水平及血压目。

Aldosterone increases the number of sodium channels and the number of potassium channels on the lumen side of the principal cell as well as sodium-potassium pumps on the basolateral side of the principal cells.

醛固可以增加主细胞内壁钠通道和钾通道数量和主细胞外壁钠钾离子泵数量。

Aldosterone is part of a hormone family or axis which work together and are called the renin-angiotensin-aldosterone system.

醛固属于一特定激素家族或激素轴一部分，这些激素共同作用，被称为肾素-血管紧张素-醛固系统。

Aldosterone has it's purpose, but it's not a hormone you want to regularly have high levels of.

醛固有其作用，但在人体中，这种荷尔蒙水平不能太高。

The diagnosis of hyperaldosteronism is mainly done by measuring levels of renin and aldosterone.

醛固增多症诊断主要通过测定肾素与醛固水平来完成。

Other pathological conditions that cause increased aldosterone levels include compensated heart failure and cirrhosis.

其他导致醛固水平增加病理状况包括代偿期心衰和肝硬化。

In particular, it's implicated in oxidative stress and myocardial fibrosis — an abnormal thickening of the heart valves.

醛固与氧化应激和心肌纤维化（心脏瓣膜异常增厚）尤其相关。