NK cell will trigger effector functions(cytolysis) by KAR,if target cell loses appropriate ligands recognized by KIR.
如胞失去KIR所识别的体,NK胞即可通过KAR胞进行攻击。
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These granules contain some molecules that punch holes in the target cell's membrane by binding by binding directly to the phospholipids and creating pores. and some that cause target cells to undergo apoptosis, which is a programmed cell death.
这些颗粒内含一些能在靶细胞上打孔的分子,它们直接与磷脂结合,然后穿孔;还有一些能够导致靶细胞凋亡,即程序细胞死亡。