She knows every nook and cranny of the city, so she’s the perfect guide.

她对这个城市了如指掌，让她做再好不过了。

She knows the layout of the back streets like the back of her hand.

她对那些偏僻的街了如指掌。

She knows physiology from beginning to end.

她对生学这门学科了如指掌。

Tony is very hot on local history.

托尼对当地历史了如指掌。