fluorouracil

Doxifluridine was facilely synthesized from 5-fluorouracil in overall yield of 54.6% via trimethyl silylation, condensation, saponification, ketal formation, iodation, hydrogenolysis and hydrolysis.

以5-尿嘧为原经硅醚、和四乙酰核糖缩合、皂、酮缩醇形成、碘、氢解及水解等反应合成了去氧尿苷。本法工艺简便、条件缓和、原易得、成本低,总收率达54.6

Purpose: Options for single-agent fluoropyrimidine adjuvant therapy after bowel cancer resection include intravenous fluorouracil with leucovorin (FU/LV) or oral capecitabine.

目的：肠道肿瘤切除术后脲嘧类单药助疗可选四氢叶酸联合尿嘧持续静脉灌注（FU/LV）或者口服卡培它滨。