Doxifluridine was facilely synthesized from 5-fluorouracil in overall yield of 54.6% via trimethyl silylation, condensation, saponification, ketal formation, iodation, hydrogenolysis and hydrolysis.
以5-氟尿嘧啶为原料经硅
、
四乙酰核糖缩
、皂、酮缩醇形成、碘、氢解及水解等反应成了去氧氟尿苷。本法工艺简便、条件缓、原料易得、成本低,
达54.6
