Doxifluridine was facilely synthesized from 5-fluorouracil in overall yield of 54.6% via trimethyl silylation, condensation, saponification, ketal formation, iodation, hydrogenolysis and hydrolysis.
以5-氟尿嘧啶为原料经硅醚化、和四乙酰核糖缩合、皂化、酮缩醇形成、碘化、氢
等反应合成了
氧氟尿苷。本法
便、条件缓和、原料易得、成本低,总收率达54.6
审核，其表达内容亦不代表本软件的观点；若发现问题，欢迎向我们指正。
