The synthesis of epalrestat,an aldose reductase inhibitor, was improved. The yield of its intermediate 3-carboxymethyl rhodanine was raised to 76.4%.
对醛搪还原酶抑制剂依帕司他的合成工艺作了改进，使中间体
乙酸的收率
高到76．4％。
[酸]The synthesis of epalrestat,an aldose reductase inhibitor, was improved. The yield of its intermediate 3-carboxymethyl rhodanine was raised to 76.4%.
对醛搪还原酶抑制剂依帕司他的合成工艺作了改进，使中间体乙酸的收率高到76．4％。
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