Recently, it has been shown that the Mitochondrial aldehyde dehydrogenase is responsible for the bioactivation of nitroglycerin prior to the release of NO, which is a strong vasodilator.
近来,有研究表明线醛脱氢酶是内催化硝酸甘油生物转化主要途径,线醛脱氢酶同时具有脱氢酶和酯酶催化活性,其酯酶活性可以通过将硝酸甘油脱硝形成一氧化氮,进而血管扩张。