Conclusions: In order to reduce the incidence of neonatal unconjugated hyperbilirubinemia, more emphasis should be put on the health care of the perinatal period.
Recycling of that heme group yields unconjugated bilirubin, which at high concentration can cause scleral icterus, jaundice, and bilirubin gall stones.
And, since the liver usually conjugates bilirubin, there'll be increased unconjugated bilirubin in the blood from a less-functional liver and that can lead to jaundice.
Well the vast majority is conjugated, but there is a small amount of unconjugated bilirubin in bile, only about 1-2% of total bilirubin, which is only 1% of bile.
With extravascular hemolysis, we have macrophages eating up red blood cells more than normal and unconjugated bilirubin production is ramped up, which is conjugated by the liver and sent to the gallbladder.